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Ibutamoren, also known as MK-677, ibutamoren is a selective agonist for the growth hormone-releasing hormone (GHRH) which is released by neurons that are located in the hypothalamus. This drug binds to the somatostatin receptors that are found on cells of postsynaptic origin, which leads to an increase in GHRH release.
The present study examines the drug Ibutamoren as a potential treatment for muscle-wasting diseases such as cachexia, sarcopenia and muscle atrophy. The drug has been tested in various different rodent papers and has shown promising results in terms of increasing fat mass and improving bone turnover. It specifically acts by increasing the amount of IGF-1 produced by the liver and also by promoting protein synthesis in skeletal muscle cells.
In November 2016, the FDA issued a notice about a drug called MK-677. The purpose of the notice was to warn people that MK-677 is banned in the US due to its lack of efficacy and it’s potential risk for long-term use. In general, the drug is marketed as an medical treatment for muscle wasting conditions, such as muscle degeneration caused by sedentary lifestyle or aging.
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